Dennis Osadebay University, Asaba is one of the three new universities established by the Delta State government and approved by the National Universities Commission (NUC) in 2021.

In January 2021, Governor Ifeanyi A Okowa of Delta State announced plans to convert Delta State University, Anwai Campus Asaba and two other schools such as Delta State Polytechnic, Ozoro and College of Education, Agbor into a full-fledged University. The bills had their first reading during plenary at the Delta State House of Assembly on the 28th day of January 2021.[5] In February 2021, the bills were passed into law after going through the House Committee on Education.